Neurodegenerative diseases

Neurodegenerative diseases include a cluster of progressive chronic diseases that are categorized by the steady damage of neurons in separate locations of the Central Nervous System (Gao and Hong 2008, 357). Examples of such conditions include amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson’s disease, frontotemporal dementia (FTD), spinocerebellar ataxias and Alzheimer's disease. The neuromuscular junction of a neuron is quite an extraordinary structure that is specifically vulnerable to the neurodegenerative diseases. Nonetheless, it has powerful mechanisms of resisting injury so that it can regenerate (Aaron et al. 2017, 501). The commonly altered cellular pathways of neurodegenerative disorders include transcriptional, protein and mitochondrial homeostasis. For instance, considering Alzheimer's disease (AD), the disorder is commonly referred to as a synaptopathy, which means there is either damage or loss of the synapses. This damage or loss of the synapses causes an altered neuronal circuitry (Montie 2013, 194). Today, about five million American citizens are suffering from Alzheimer's disease; one million United States inhabitants have Parkinson's disease; four hundred thousand have multiple sclerosis (MS); three hundred thousand have amyotrophic lateral sclerosis (ALS), and approximately thirty thousand have Huntington's disease. Since neurodegenerative diseases strike mainly from mid- to late-life, the occurrence is expected to ascend as the populace ages. If the situation is left unchecked,…

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